Case study: Gaining insight into cortical neuron differentiation
In their recent publication, Prof. Bassem Hassan, director of research at the Paris Brain Institute, and his team found that human brain development is vulnerable to the loss of the amyloid precursor protein (APP), which is known for its involvement in Alzheimer’s disease. This discovery was made by looking into how APP regulates the fate of human cortical neuroprecursor cells derived from human iPSCs.
The team used the Asteria kit technology to compare control neuronal progenitor cells to an APP knock-out model. The results showed a clear emergence of a separate cell cluster in the knock-out condition with unexpectedly mature features. Further experiments confirmed that APP loss accelerates neuronal differentiation, and that APP is important for timely neural development.
Deciphering the heterogeneity of glial cells
The Asteria and Cytonaut technology have also proven effective at capturing and identifying non-neural cells in brain samples from mice.
Two teams from the Paris Brain Institute have successfully used the benchtop kit in neuroscience in order to:
- Decipher the heterogeneity of a human-derived cerebral organoid model.
- Characterize in detail the cell diversity of glial lineages from mouse oligodendrocyte progenitor cells.
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