Scipio bioscience has a long-standing collaboration with Prof. Bassem Hassan, Scientific Director and Head of the Brain Development Team at the Paris Brain Institute. Using the RevGel-seq technology patented by Scipio bioscience, we were able to identify new cell subtypes on knock-out models highlighting the role of APP proteins in neuron development.

The RevGel-seq technology enabled us to process neural precursor cells and their APP knockout counterparts and to demonstrate the presence of neurogenic progenitors, expressing both radial glial markers and neuronal differentiation markers in APPKO cells.

The results of this study have now been published.